St James's is home to a good number of art galleries covering a wide range of tastes. The White Cube gallery, which represents Damien Hurst and Tracey Emin, originally opened in Duke Street before moving to Hoxton Square. A second gallery opened on the road to replace it.

St James's Park is the oldest of the Royal parks in London. Originally, Marble Arch existed at its entrance, before it was moved in 1851 and replaced with the Victoria Memorial.

St James's Palace exists on the site of St James's Hospital. The 12th century hospital was founded for the upkeep and detention of 14 leprous maidens. They lie buried in one of the inner courtyards, where their graves, marked by small crosses, can still be seen.

At number 69 St James’s is the site of the Carlton Club, originally known as Arthur's because it was founded in 1832 by Arthur Wellesley, Duke of Wellington.